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Key Tumor Responsive ZIF-8 Nanocarriers for Effective Anti-Cancer Therapeutics
Wenjing He1, Haiyu Hu1, Zhuochen Yu1
1School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.
International Journal of Nanomedicine
|May 19, 2026
Summary
Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles overcome therapeutic resistance by delivering drugs and remodeling the tumor microenvironment (TME). This dual action enhances antitumor efficacy and offers a promising strategy for next-generation cancer nanotheranostics.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Cancer Therapy
Background:
- Tumor microenvironment (TME) complexity drives therapeutic resistance.
- Conventional treatments face limitations due to TME-mediated resistance.
Purpose of the Study:
- To review the dual role of Zeolitic Imidazolate Framework-8 (ZIF-8) in drug delivery and TME modulation.
- To explore ZIF-8's potential in overcoming therapeutic resistance and advancing nanotheranostics.
Main Methods:
- Review of recent research on ZIF-8 synthesis, drug delivery applications, and Zn2+ release mechanisms.
- Analysis of ZIF-8's integration into theranostic platforms and combination therapies.
- Examination of clinical translation challenges, including biosafety and scalability.
Main Results:
- ZIF-8 acts as a pH-responsive drug carrier and releases Zn2+ to remodel the TME.
- Released Zn2+ induces cellular stress responses and modulates immune reactions.
- ZIF-8 demonstrates potential in targeted drug delivery and synergistic therapeutic effects.
Conclusions:
- ZIF-8 offers a synergistic approach to mitigate therapeutic resistance through combined drug delivery and TME modulation.
- Further research and development are needed to address clinical translation challenges for ZIF-8 nanotheranostics.
- ZIF-8 holds promise for developing advanced cancer nanotheranostic systems.
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