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Single-Probe Triple-Emission Eu/Tb-MOF Sensor Array for Multidimensional Discrimination of Amino Acids.

Xue Wang1, Yuting Chen1, Yuzhe Tang1

  • 1School of Chemical and Environmental Engineering, Jilin Provincial Science and Technology Innovation Centre of Optical Materials and Chemistry, Jilin Provincial International Joint Research Center of Photo-functional Materials and Chemistry, Changchun University of Science and Technology, Changchun 130022, People's Republic of China.

Analytical Chemistry
|May 19, 2026
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Researchers developed a novel bimetallic Europium/Terbium-Metal-Organic Framework (Eu/Tb-MOF) for amino acid detection. This triple-emission MOF achieves 100% accuracy in distinguishing similar amino acids and has security applications.

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Area of Science:

  • Materials Science: Synthesis and characterization of novel lanthanide-based Metal-Organic Frameworks (Ln-MOFs).
  • Analytical Chemistry: Development of fluorescence-based sensing platforms for complex mixture analysis.

Background:

  • Metal-Organic Frameworks (MOFs) offer tunable properties for diverse applications.
  • Lanthanide ions (Eu3+, Tb3+) exhibit unique luminescent characteristics crucial for sensing and imaging.

Purpose of the Study:

  • To synthesize a bimetallic Eu/Tb-MOF with multiple emission centers for enhanced sensing capabilities.
  • To develop a single-probe fluorescence sensor array for accurate discrimination of structurally similar amino acids.
  • To explore the application of the synthesized MOF in information concealment and anticounterfeiting.

Main Methods:

  • Mixed-lanthanide strategy for synthesizing a bimetallic Eu/Tb-MOF.
  • Single-wavelength excitation to achieve triple-color fluorescence fingerprint (ligand, Eu3+, Tb3+ emissions).
  • Construction of a single-probe fluorescence sensor array for amino acid discrimination.
  • Characterization using FTIR, UV-vis spectroscopy, and fluorescence lifetime analysis.

Main Results:

  • Successful synthesis of a bimetallic Eu/Tb-MOF exhibiting ligand-centered emission (400 nm) and characteristic Eu3+ (615 nm) and Tb3+ (545 nm) emissions.
  • Achieved 100% classification accuracy in discriminating 10 structurally similar amino acids using the fluorescence sensor array.
  • Demonstrated reliable analytical performance in real samples like honey and juice.
  • Identified ground-state interactions involving amino-, hydroxyl-, and carboxylate groups of amino acids with the Eu/Tb-MOF.

Conclusions:

  • The developed Eu/Tb-MOF provides a simple and efficient platform for multidimensional amino acid discrimination.
  • The material shows significant potential for integrated sensing and advanced security applications, including fluorescent inks and anticounterfeiting coatings.
  • This work highlights the versatility of multifunctional Ln-MOFs in addressing complex analytical challenges.