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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Choroidal melanoma and polydactylous onychopapilloma leading to diagnosis of <i>BAP1</i> tumor predisposition syndrome.

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Comment on Rivas et al. Unexpectedly Low Rate of Metastasis and Death Among Patients Treated for Uveal Melanoma with Brachytherapy, Vitrectomy, and Silicone Oil. <i>Cancers</i> 2025, <i>17</i>, 2683.

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Related Experiment Video

Updated: May 20, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Ring Melanoma: from Vitrectomy to Enucleation.

Deanna Ingrassia Miano1, Miguel A Materin1, Arpita Maniar1

  • 1Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27705, USA.

Retinal Cases & Brief Reports
|May 19, 2026
PubMed
Summary
This summary is machine-generated.

This case study highlights a rare ring melanoma that initially evaded detection. The rare eye tumor progressed over 13 months, leading to enucleation despite negative initial workups.

Keywords:
enucleationneovascular glaucomaretinoinvasionring uveal melanomavitrectomy

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Area of Science:

  • Ophthalmology
  • Oncology

Background:

  • Ring melanoma is a rare intraocular malignancy.
  • Early detection can be challenging due to its subclinical presentation.

Purpose of the Study:

  • To document the disease progression of a ring melanoma.
  • To illustrate the diagnostic challenges associated with this rare condition.

Main Methods:

  • A comprehensive chart review was performed.
  • Diagnostic and therapeutic vitrectomy were utilized.
  • Ocular imaging and histopathological analysis were conducted.

Main Results:

  • A 75-year-old male presented with symptoms suggestive of intraocular disease but no visible mass.
  • Melanoma cells were detected via vitrectomy, but initial workup was negative.
  • After 13 months, imaging revealed a ciliary body mass, confirmed as ring melanoma post-enucleation, with iris and retinal involvement.

Conclusions:

  • Ring melanoma can present insidiously and evade initial clinical and imaging assessments.
  • This case underscores the importance of considering rare diagnoses in persistent ocular symptoms.
  • The disease course demonstrates progression from subclinical to advanced ocular infiltration.