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Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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Impact of Obstetric Complications in Subjects at Clinical High Risk for Psychosis: A Systematic Review and

Inmaculada Baeza1,2,3,4, Jordina Tor5,6, Elena de la Serna1,2,3

  • 1Department of Child and Adolescent Psychiatry and Psychology, SGR2021-01319, Institute of Neuroscience, Hospital Clínic of Barcelona, Barcelona, Spain.

Acta Psychiatrica Scandinavica
|May 19, 2026
PubMed

Insights

Obstetric complications (OCs) are more common in individuals clinically at high risk for psychosis (CHR). While OCs are linked to CHR, their role in psychosis transition needs more research.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Perinatal Medicine

Background:

  • Obstetric complications (OCs) are known risk factors for psychosis and schizophrenia in offspring.
  • Previous studies on OCs in individuals clinically at high risk for psychosis (CHR) yielded inconsistent findings.
  • A systematic review and meta-analysis were conducted to clarify the association between OCs and CHR individuals.

Purpose of the Study:

  • To determine the prevalence of OCs in CHR individuals compared to controls.
  • To investigate the impact of OCs on the transition to psychosis in CHR individuals.

Main Methods:

  • Systematic search of four databases (Web of Science, PubMed, Latindex, Dialnet) from 1995 to June 2024.
  • Risk of bias assessment using the Newcastle-Ottawa scale.
  • Meta-analysis of data from nine eligible articles including 555 CHR participants.

Main Results:

  • A significantly higher prevalence of OCs was found in CHR subjects compared to controls (RR = 1.45, p = 0.0011).
  • A trend towards increased risk of transition to psychosis was observed in CHR subjects with a history of OCs (RR = 2.05, p = 0.056).

Conclusions:

  • Clinical high risk for psychosis (CHR) is associated with obstetric complications (OCs).
  • The specific role of OCs in the transition to psychosis warrants further investigation.
  • Recording and analyzing OCs in CHR individuals is recommended due to potential clinical significance.
Abstract

Keywords:
clinical high riskobstetric complicationsoutcomepregnancy and deliverypsychosis riskpsychotic disordertransition to psychosis

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