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Effect of Green Tea Extract Supplementation on Substrate Utilization: A GRADE-Assessed Systematic Review and
Amir Hossein Khalilkhaneh1,2, Mohammad Vesal Bidsheki3,4, Salih M S Zebari5,6
1Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Nutrition Reviews
|May 19, 2026
Summary
Green tea extract (GTE) supplementation boosts fat oxidation during and after exercise. This meta-analysis confirms GTE
Area of Science:
- Exercise Physiology
- Nutritional Biochemistry
- Sports Science
Background:
- Existing research on green tea extract (GTE) and substrate oxidation lacks consensus.
- Previous studies exhibit heterogeneous results, necessitating a meta-analysis.
- No prior meta-analysis has comprehensively evaluated GTE's impact on substrate oxidation.
Purpose of the Study:
- To systematically review and meta-analyze the effects of GTE supplementation on substrate oxidation.
- To specifically investigate GTE's influence on fat and carbohydrate oxidation during and post-exercise.
- To critically evaluate the existing evidence on GTE and exercise metabolism.
Main Methods:
- Comprehensive literature search across PubMed, Web of Science, and Scopus databases.
- Inclusion of eligible randomized controlled trials (RCTs) reporting substrate oxidation data.
- Evidence certainty assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) method.
Main Results:
- GTE supplementation significantly increased fat oxidation during exercise (WMD: 0.2 g/min) and after exercise (WMD: 0.04 g/min).
- GTE significantly decreased carbohydrate oxidation after exercise (WMD: -0.16 g/min) but not during exercise.
- Dose-response analysis indicated higher GTE doses augment post-exercise fat oxidation.
Conclusions:
- GTE supplementation effectively enhances fat oxidation during and after exercise.
- The impact of GTE on carbohydrate oxidation is limited, particularly during exercise.
- Evidence quality ranged from low to high based on GRADE criteria.
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