Related Experiment Video
Updated: May 21, 2026

08:38
Three-dimensional Navigation-guided, Prone, Single-position, Lateral Lumbar Interbody Fusion Technique
Published on: July 15, 2021
Bicortical Lateral Plate Screw Placement Reduces Subsidence Risk in Patients Undergoing Lateral Lumbar Interbody
Samuel H Wakelin1, Anthony Schulien1, Benjamin J Carnovale1
1Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
World Neurosurgery
|May 19, 2026
Summary
Bicortical screw placement in Lateral Lumbar Interbody Fusion (LLIF) may reduce postoperative subsidence. This technique, unlike unicortical screws, appears protective against subsidence, enhancing LLIF outcomes.
Area of Science:
- Spine surgery
- Orthopedic surgery
- Minimally invasive spine procedures
Background:
- Lateral Lumbar Interbody Fusion (LLIF) is a minimally invasive technique for neural decompression.
- Postoperative subsidence remains a significant complication following LLIF procedures.
- Understanding factors influencing subsidence is crucial for improving patient outcomes.
Purpose of the Study:
- To investigate the impact of lateral plate screw placement techniques on postoperative subsidence after LLIF.
- To identify specific screw placement strategies that may mitigate subsidence risk.
- To analyze the relationship between screw type and subsidence rates.
Main Methods:
- Retrospective review of 144 patients (218 levels) from 2014-2022 at two quaternary centers.
- Radiographic assessment of subsidence, bony fusion, and screw length.
- Statistical analysis including T-tests, Chi-squared/Fisher's exact tests, and logistic regression.
Main Results:
- 12% of operative levels (27/218) experienced subsidence.
- Subsidence rates varied significantly with cage material, lateral plating, number of levels, and screw type.
- Multivariate analysis indicated bicortical screws significantly reduced subsidence odds (OR: 0.291, p=0.016).
- Unicortical screws did not show a significant reduction in subsidence odds compared to no plating (OR: 0.402, p=0.125).
Conclusions:
- Bicortical screw placement appears to be a protective factor against postoperative subsidence in LLIF.
- This finding suggests optimizing screw technique can improve LLIF safety and efficacy.
- Further research may validate bicortical screw placement as a standard preventative measure for subsidence.
