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Updated: May 21, 2026
Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
The associations between volatile organic compounds and bone loss around teeth among US adults
Luyun Wei1, Shengzhu Huang2, He Huang3
1Clinical Research Center, the Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China. efy11296@sr.gxmu.edu.cn.
Background:
Volatile organic compounds (VOCs) represent significant contributors to air pollution. Their exposure has been associated with a range of human diseases. Nevertheless, the impact of VOCs on bone loss around teeth (BLAT) remains unclear and has yet to be fully evaluated.
Objective:
The aim of this study was to investigate the association between VOCs exposure and BLAT.
Methods:
This study included 4,345 participants and utilized data from four cycles of NHANES (2011-2020) to analyze the association between VOCs exposure and BLAT using multivariable logistic regression and restricted cubic splines (RCS).
Results:
After full adjustment for covariates, the highest quartile concentrations of three VOCs were significantly associated with an increased risk of BLAT: URXAAM (OR = 1.69, 95% CI: 1.15-2.48), URXAMC (OR = 1.53, 95% CI: 1.10-2.12), and URXCYM (OR = 1.35, 95% CI: 1.02-1.80). Stratified analysis revealed that the types and number of VOCs positively associated with BLAT varied across different subgroups. RCS analysis showed that five VOCs (URX2MH, URXAAM, URXCYM, URXMB3, and URXPMM) exhibited a linear positive association with BLAT risk, while URXAMC showed a non-linear relationship (P for overall trend < 0.05 for all).
Conclusion:
Exposure to specific VOCs is associated with an increased risk of BLAT.
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