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Related Experiment Video

Updated: May 21, 2026

Direct Agroinoculation of Maize Seedlings by Injection with Recombinant Foxtail Mosaic Virus and Sugarcane Mosaic Virus Infectious Clones
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Published on: February 27, 2021

ZmNPSN13 Potentiates Maize Rough Dwarf Disease Upon Recruitment by the RBSDV P7-1 Effector.

Suining Deng1, Yixiao Qin1, Baoshen Liu2

  • 1State Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.

Molecular Plant Pathology
|May 20, 2026
PubMed
Summary

Maize rough dwarf disease (MRDD) is controlled by targeting the viral effector P7-1. Scientists found that ZmNPSN13 protein disruption enhances maize resistance to MRDD by restoring hormonal balance.

Keywords:
ZmGDIα‐helmaize rough dwarf diseasephytohormoneplant SNARE protein

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Last Updated: May 21, 2026

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Agrobacterium-Mediated Immature Embryo Transformation of Recalcitrant Maize Inbred Lines Using Morphogenic Genes

Published on: February 14, 2020

Area of Science:

  • Plant Pathology
  • Molecular Biology
  • Virology

Background:

  • Maize rough dwarf disease (MRDD), caused by fijiviruses, significantly impacts global maize production.
  • Rice black-streaked dwarf virus (RBSDV) is a primary cause of MRDD in Asia.
  • Viral effector P7-1 hijacks host factor ZmGDIα, initiating disease, while ZmGDIα-hel variant confers resistance.

Purpose of the Study:

  • To identify novel host targets of the viral effector P7-1.
  • To elucidate the mechanism of P7-1-mediated MRDD pathogenesis.
  • To explore ZmNPSN13 as a potential target for engineering disease resistance.

Main Methods:

  • Protein interaction studies to identify P7-1 targets.
  • Analysis of ZmNPSN13 function in host-pathogen interactions.
  • Gene knockout experiments to assess resistance mechanisms.
  • Phytohormone level analysis in infected maize.

Main Results:

  • ZmNPSN13, a Qb-SNARE protein, was identified as a new target of P7-1.
  • ZmNPSN13 acts as a hub, linking ZmGDIα and ZmGA2ox7.3.
  • P7-1 forms a complex with ZmNPSN13, ZmGDIα, and ZmGA2ox7.3, disrupting phytohormone balance.
  • ZmNPSN13 knockout restored hormonal homeostasis and enhanced MRDD resistance.

Conclusions:

  • The viral effector P7-1 exploits SNARE-mediated vesicle trafficking to disrupt host immunity.
  • ZmNPSN13 plays a critical role in MRDD pathogenesis by modulating phytohormone levels.
  • ZmNPSN13 is a promising target for developing MRDD-resistant maize varieties.