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Related Concept Videos

Gastric Emptying01:16

Gastric Emptying

Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...

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Related Experiment Video

Updated: May 21, 2026

Roux-en-Y Gastric Bypass Operation in Rats
07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

Roux-en-Y gastric bypass: Pilot study results from a resource constrained setting.

A Khamajeet1, A Diab1, T Biesman-Simons1

  • 1Division of General Surgery, Department of Surgery, New Somerset Hospital, University of Cape Town, South Africa.

South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
|May 20, 2026
PubMed
Summary
This summary is machine-generated.

Roux-en-Y gastric bypass (RYGB) is effective for weight loss and comorbidity resolution in South Africa's low-resource settings. This pilot study shows significant improvements in obesity-related conditions over three years.

Keywords:
comorbidity resolutionexcess BMI lossexcess weight lossmetabolic and bariatric surgeryobesitytotal weight loss

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Last Updated: May 21, 2026

Roux-en-Y Gastric Bypass Operation in Rats
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Published on: June 11, 2012

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
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One-anastomosis Gastric Bypass (OAGB) in Rats
08:16

One-anastomosis Gastric Bypass (OAGB) in Rats

Published on: November 10, 2018

Area of Science:

  • Bariatric Surgery
  • Public Health
  • Metabolic Disorders

Background:

  • Obesity is a global health crisis with severe consequences.
  • Metabolic and bariatric surgery (MBS) offers sustained weight loss and improved comorbidities.
  • MBS accessibility is limited in South Africa's public sector due to high costs.

Purpose of the Study:

  • To assess the outcomes of Roux-en-Y gastric bypass (RYGB) in a resource-constrained South African setting.
  • To evaluate weight loss, comorbidity resolution, and complication rates over a 3-year period.
  • To determine the feasibility of MBS in a low-resource public healthcare environment.

Main Methods:

  • Retrospective analysis of 17 patients undergoing RYGB.
  • Data collected from August 2017 to February 2020 at New Somerset Hospital, South Africa.
  • Primary outcomes: percentage total weight loss (%TWL), excess weight loss (%EWL), excess BMI loss (%EBMIL). Secondary outcomes: comorbidity resolution (T2D, hypertension, GERD, dyslipidemia).

Main Results:

  • Mean BMI reduced from 48.3 to 38.35 kg/m² at 3 years.
  • Significant weight loss achieved: %TWL 20.3%, %EWL 42.5%, %EBMIL 43.2%.
  • Comorbidity resolution rates: 50% for type 2 diabetes, 71.4% for GERD, 66.7% for dyslipidemia. Low complication rate (one port site hernia).

Conclusions:

  • MBS is feasible and effective in resource-constrained settings like South Africa.
  • RYGB shows significant potential for managing the obesity epidemic and its comorbidities.
  • Further research with larger cohorts and longer follow-up is recommended to validate findings.