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Updated: May 21, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

Discovery and Structural Optimization of BRD4-Selective Monovalent Direct Degraders

Geoffray Leriche1, Farhana Barmare1, Julia I Toth1

  • 1Plexium, 9330 Scranton Road, San Diego, California 92121, United States.

ACS Medicinal Chemistry Letters
|May 20, 2026
PubMed
Abstract

Keywords:
BRD4DCAF11medicinal chemistry optimizationmonovalent direct degradertargeted protein degradation

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