Targeted Modulation of YAP Signaling: Advancing Small-Molecule Strategies in Oncology and Tissue Regeneration
Anna C Renner1, Robert B Kargbo2
1North Dakota State University, Fargo, North Dakota 58108-6050, United States.
Abstract:
The Hippo-YAP pathway has emerged as a central regulator of tissue growth and oncogenesis, yet remains resistant to conventional pharmacological targeting. Patent application WO 2026/044133 A1 discloses small-molecule strategies that modulate YAP activity through transcriptional complex disruption and protein stability interference. Robust cellular validation across YAP-dependent cancer models establishes proof of concept for tractable YAP inhibition, with implications spanning oncology and regenerative medicine.
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