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Integrative bibliometric and transcriptomic analyses identify selenium-associated molecular signatures in the aging
Shan Liu1,2, Bo Yan3, Han Gao1,2
1Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.
Frontiers in Aging Neuroscience
|May 20, 2026
Summary
This study identifies SP1 and SEPHS2 as key genes linking selenium to brain aging. These findings offer new insights into selenium
Area of Science:
- Neuroscience
- Genetics
- Biochemistry
Background:
- The aging brain is susceptible to changes in selenium levels.
- Selenium deficiency is linked to cognitive decline and neurodegeneration.
- Molecular links between selenium and brain aging are not well understood.
Purpose of the Study:
- To identify key genes connecting selenium status to brain aging.
- To explore potential biomarkers and therapeutic targets for brain aging.
Main Methods:
- Bibliometric analysis of 1,826 publications.
- Identification of differentially expressed genes (DEGs) in brain aging.
- Machine learning, SHAP, and nomogram analyses to prioritize core genes.
- Validation in an independent cohort and mouse brain tissue.
Main Results:
- Bibliometric analysis revealed increasing research on selenium and aging, with a focus on oxidative stress and selenoproteins.
- Seven potential targets were identified, with SP1 and SEPHS2 prioritized by machine learning.
- SP1 and SEPHS2 expression changes were confirmed in aged mouse brains at mRNA and protein levels.
Conclusions:
- SP1 and SEPHS2 are identified as key genes linking selenium to brain aging.
- These genes may serve as potential biomarkers or therapeutic targets for brain aging and related disorders.
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