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ABHD11-AS1 Suppresses Colorectal Cancer Progression by Disrupting EIF4E-mediated POU2F1 Ubiquitination

Shizhen Li1,2, Xianjie Jiang1,2, Linda Oyang1,2

  • 1Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

International Journal of Biological Sciences
|May 20, 2026
PubMed

Insights

A novel long non-coding RNA, ABHD11-AS1, acts as a tumor suppressor in colorectal cancer (CRC). Its downregulation promotes CRC progression and chemoresistance, revealing a new therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal cancer (CRC) is a major global health concern with incompletely understood progression mechanisms.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cancer regulation.
  • Identifying novel regulatory pathways is crucial for developing effective CRC therapies.

Purpose of the Study:

  • To investigate the role of ABHD11-AS1, a specific lncRNA, in colorectal cancer.
  • To elucidate the molecular mechanisms underlying ABHD11-AS1's function in CRC.
  • To assess the therapeutic potential of ABHD11-AS1 in CRC treatment.

Main Methods:

  • Gene expression analysis in CRC tissues.
  • In vitro functional assays (proliferation, migration, invasion).
  • Chemotherapy sensitivity assays.
  • Molecular mechanism studies involving protein-protein interactions and translation regulation.

Main Results:

  • ABHD11-AS1 was found to be significantly downregulated in CRC tissues, correlating with poor prognosis.
  • ABHD11-AS1 suppressed CRC cell proliferation, migration, and invasion, and increased oxaliplatin sensitivity.
  • ABHD11-AS1 inhibits USP18 translation by disrupting EIF4E phase separation, leading to POU2F1 degradation.

Conclusions:

  • ABHD11-AS1 functions as a tumor suppressor in colorectal cancer.
  • The ABHD11-AS1/EIF4E/USP18/POU2F1 axis represents a novel regulatory pathway in CRC.
  • ABHD11-AS1 holds promise as a potential therapeutic target for CRC, enhancing treatment efficacy.
Keywords:
ABHD11-AS1EIF4EPOU2F1colorectal cancerphase separationubiquitination

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