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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Updated: May 21, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
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Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Precision medicine in paediatrics: Progress and priorities.

Nicola Husain1,2, Claire Booth1,3, Joseph F Standing1,4,5

  • 1Infection, Immunity and Inflammation Research & Teaching Department, UCL GOS Institute of Child Health, London, UK.

British Journal of Clinical Pharmacology
|May 20, 2026
PubMed
Summary

Paediatric precision medicine uses pharmacogenomics and pharmacometrics to tailor drug treatments for children, improving safety and efficacy. Advanced therapies offer new hope, but challenges in cost and implementation remain.

Keywords:
advanced therapy medicinal productsgene therapymodel‐informed precision dosingpersonalized medicinepharmacogenomicspharmacometrics

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Whole-body PET/MRI of Pediatric Patients: The Details That Matter
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Whole-body PET/MRI of Pediatric Patients: The Details That Matter

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Area of Science:

  • Paediatric medicine
  • Pharmacogenomics
  • Pharmacometrics
  • Advanced therapy medicinal products

Background:

  • Precision medicine personalizes healthcare based on individual patient profiles.
  • Paediatric precision medicine leverages advances in genetics and quantitative pharmacology.
  • Traditional 'trial-and-error' prescribing in children leads to suboptimal outcomes and toxicity.

Purpose of the Study:

  • To review the evolving landscape of paediatric precision medicine.
  • To examine advances in pharmacogenomics, pharmacometrics, and advanced therapies.
  • To demonstrate how these innovations can optimize paediatric clinical care and therapeutic strategies.

Main Methods:

  • Review of pharmacogenomic principles and their application in paediatrics.
  • Analysis of pharmacometric techniques, including population pharmacokinetic-pharmacodynamic modeling.
  • Examination of advanced therapy medicinal products (e.g., gene therapies) in paediatric disease treatment.

Main Results:

  • Pharmacogenomics can reduce drug toxicity and accelerate the identification of effective paediatric treatments.
  • Pharmacometrics provides data-driven dosing guidelines for special paediatric populations.
  • Advanced therapies are advancing paediatric disease treatment, necessitating new funding models.

Conclusions:

  • Paediatric precision medicine holds significant potential for improving child healthcare outcomes.
  • Implementation challenges include cost, workforce readiness, governance, and equity.
  • Continued research is crucial for integrating novel precision medicine technologies into paediatric practice.