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High Rates of Seroprotection for Measles in Pediatric Patients With Inflammatory Bowel Disease
Freddy Caldera1, Mary S Hayney2, Jennifer A Strople3
1Department of Medicine, Division of Gastroenterology and Hepatology, School of Medicine & Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Introduction:
The ongoing US measles outbreak raises concerns for immunosuppressed children with inflammatory bowel disease (IBD).
Methods:
We evaluated measles seroprotection in pediatric patients with IBD using a high-sensitivity ELISA (Zeus) compared with a standard commercial assay.
Results:
Among 176 patients, 173 (98%) were seropositive despite 87% being on immunosuppressive therapy. In comparison, only 163 (93%) were seropositive by commercial assay, resulting in a negative predictive value of 23%.
Discussion:
Children with IBD have high measles seroprotection. A negative commercial result should not be interpreted as lack of seroprotection, highlighting the need for more accurate assays.
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