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A wireless multi-parameter in-situ calibration 'chip' for real-time centrifugal
Youhong Zeng1, Hanxing Zhang1, Qi Li1
1Institute of Microfluidic Chip Development in Biomedical Engineering, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
Biomedical Microdevices
|May 20, 2026
Summary
A new wireless calibration chip simplifies monitoring of centrifugal microfluidic systems. This tool enables in-situ evaluation and calibration for improved point-of-care molecular diagnostics.
Area of Science:
- Biomedical Engineering
- Microfluidics
- Analytical Chemistry
Background:
- Centrifugal microfluidics offers automated bioanalysis for point-of-care diagnostics.
- Real-time PCR on these platforms is effective but difficult to monitor during development.
- Challenges arise from conflicting thermal, optical, and centrifugal interactions.
Purpose of the Study:
- To develop a wireless, in-situ calibration chip for centrifugal microfluidic systems.
- To address the difficulties in monitoring operational states for evaluation and calibration.
- To provide a versatile tool for system assessment.
Main Methods:
- A multi-functional calibration chip with integrated sensing, optical, fluidic, and electrical layers was designed.
- The chip incorporates temperature calibration, fluorescence simulation, fluid monitoring, and mechanical sensing.
- Wireless operation via Bluetooth and embedded rechargeable batteries was implemented.
Main Results:
- The calibration chip successfully performed multiple calibration and evaluation tasks.
- Demonstrated in-situ monitoring capabilities for centrifugal microfluidic systems.
- Validated the chip's utility as a convenient, on-hand tool for system assessment.
Conclusions:
- The developed wireless calibration chip effectively addresses the monitoring challenges in centrifugal microfluidics.
- This tool facilitates convenient in-situ calibration and evaluation, enhancing system development.
- It supports improved performance of point-of-care molecular diagnostic platforms.
