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Updated: May 21, 2026

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A Non-Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib

Aochu Liu1,2, Zhenguo Liu3, Lizhen Jiang1

  • 1Sino-French Hoffmann Institute, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|May 20, 2026
PubMed
Abstract

Keywords:
ID3core regulatory circuitferroptosisneuroendocrine differentiationnon‐small cell lung cancerosimertinib resistancesuper‐enhancer

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