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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

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  1. Home
  3. Circadian Disruption Shift Work And Breast Cancer Risk.
  1. Home
  3. Circadian Disruption Shift Work And Breast Cancer Risk.

Related Experiment Video

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Circadian Disruption Shift Work and Breast Cancer Risk.

Harini Subramanian1, Kristina Kairaitis2

  • 1Ludwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, 176 Hawkesbury Road, Westmead, New South Wales, 2145, Australia; Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, 2145, Australia.

Sleep Medicine Clinics
|May 20, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Night shift work is a probable carcinogen, increasing cancer risk by disrupting circadian rhythms with light exposure. Individual risk varies, and screening at-risk individuals is recommended.

Keywords:
Breast cancerCancer epidemiologyCircadian disruptionCircadian rhythmsLight at nightNight shift workOccupational health

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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

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Published on: September 28, 2017

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Area of Science:

  • Occupational Health
  • Chronobiology
  • Cancer Epidemiology

Background:

  • Night shift work is classified as a probable human carcinogen.
  • Disruption of circadian rhythms by light at night is the suspected mechanism.
  • Individual cancer risk is influenced by circadian sensitivity, existing risk factors, and exposure levels.

Purpose of the Study:

  • To review the evidence linking night shift work to cancer.
  • To discuss factors influencing individual cancer risk.
  • To consider appropriate risk management strategies.

Main Methods:

  • Review of epidemiologic studies in humans.
  • Analysis of mechanistic studies in animals.
  • Assessment of factors affecting individual susceptibility.

Main Results:

  • Night shift work is associated with increased cancer risk, particularly due to circadian disruption.
  • Individual risk is modulated by personal sensitivity, pre-existing conditions, and light exposure patterns.
  • No current interventions are proven to prevent night shift-related cancer risk.

Conclusions:

  • Night shift work poses a probable carcinogenic risk.
  • Further research is needed on interventions.
  • Screening individuals at higher risk is a practical approach.