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Updated: May 22, 2026

Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
IL-23 blockade: A strategy for managing pain-related inflammatory diseases
1Facultad de Educación, Universidad Alfonso X El Sabio (UAX), Avenida de la Universidad, Villanueva de la Cañada, Madrid, España.
None:
IL-23, a cytokine involved in regulating immune system activity, plays an essential role in the development and progression of pain-associated inflammatory disorders. By promoting the differentiation and activation of Th17 cells, IL-23 induces the production of pro-inflammatory cytokines, including IL-17. These pro-inflammatory cytokines are key mediators of tissue damage and chronic inflammation observed in various conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. This chapter provides a comprehensive overview of the molecular mechanisms underlying IL-23-mediated inflammation and its role in the development of pain. Additionally, the therapeutic potential of IL-23 inhibition is examined, with a particular focus on immunotherapy, through the review of clinical data that supports the high efficacy of IL-23 blockade in reducing inflammation, alleviating symptoms, and improving patient outcomes. Targeting IL-23 is seen as a promising strategy for managing inflammatory diseases, providing an alternative to conventional therapies.
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