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Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

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Related Experiment Video

Updated: May 22, 2026

Visualization and Quantitative Analysis of Embryonic Angiogenesis in Xenopus tropicalis
06:05

Visualization and Quantitative Analysis of Embryonic Angiogenesis in Xenopus tropicalis

Published on: May 25, 2017

Visualization of the Embryonic Great Vessels Using Plastic Resin Injection.

Rimshah Abid1, Yena Oh1, Kyoung-Han Kim2

  • 1Heart Institute, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

Methods in Molecular Biology (Clifton, N.J.)
|May 20, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a new resin injection technique to visualize fetal mouse vasculature. This method accurately captures the great vessels, aiding in the study of cardiovascular development and congenital heart defects.

Keywords:
Arch artery defectsCongenital heart diseaseGreat vesselsPlastic resin casting

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Last Updated: May 22, 2026

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Area of Science:

  • Developmental biology
  • Cardiovascular research
  • Medical imaging

Background:

  • Accurate visualization of embryonic vasculature is crucial for understanding cardiovascular development.
  • Congenital heart defects arise from abnormalities during embryonic development.
  • Existing methods may lack the resolution or stability for detailed vascular analysis.

Purpose of the Study:

  • To present a novel protocol for creating detailed vascular casts of rodent embryos.
  • To enable precise visualization of the great vessels and fine vascular architecture.
  • To facilitate the detection of cardiovascular abnormalities in embryonic development.

Main Methods:

  • A low-viscosity plastic resin is injected into the fetal mouse heart.
  • The resin polymerizes in situ, forming stable casts of the vascular network.
  • These casts preserve intricate vascular details for subsequent analysis.

Main Results:

  • The protocol successfully created stable casts of the great vessels.
  • The casts preserved fine vascular architecture, revealing normal and abnormal structures.
  • The method allowed for the detection of specific anomalies like aortic arch artery anomalies and ventricular septal defects.

Conclusions:

  • This resin injection technique offers a robust and reproducible method for studying embryonic cardiovascular systems.
  • The protocol aids in investigating both normal cardiovascular development and the origins of congenital heart defects.
  • This approach enhances the ability to analyze pathological cardiovascular networks in rodent embryos.