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Quality-of-Life Recovery in Cushing's Disease: A Cluster Analysis
Adam Zachary Levitan1,2, Jai Sethi1, Ali Ammar1
1Neurosurgery, https://ror.org/04skqfp25St Michael's Hospital, Canada.
Summary
Successful Cushing's disease surgery improves patient quality of life, though some experience worsening symptoms. Post-operative support is crucial for managing these changes and improving emotional and physical health.
Area of Science:
- Endocrinology
- Surgical Outcomes
- Quality of Life Research
Background:
- Cushing's disease (CD) surgery causes abrupt cortisol changes, impacting patient quality of life (QOL).
- Characterizing QOL changes pre- and post-CD surgery is essential for patient management.
Purpose of the Study:
- To detail QOL changes in patients before and after successful Cushing's disease surgery.
- To identify patterns and predictors of QOL recovery post-CD surgery.
Main Methods:
- Administered the QOL-CD questionnaire pre- and post-surgery.
- Utilized descriptive statistics, nonparametric tests, and Euclidean hierarchical clustering.
- Analyzed clinical, endocrinological, and ophthalmological attributes.
Main Results:
- Overall improvement in hypertension, emotional health, and physical health post-surgery.
- Emotional health changes correlated with mental status and social well-being.
- Cluster analysis identified three QOL change patterns: worsening (n=5), marginal (n=20), and improvement (n=9).
Conclusions:
- Patient education and support are vital before and after CD surgery.
- Long-term follow-up is needed to understand QOL recovery trajectories.
- Identifying predictors of treatment response can optimize patient outcomes.
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