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2-(2-Pyridyl)ethyl (Pet): An Electroresponsive Protecting Group for O/N Functionalities

Xin Wang1, Lianyou Zheng1, Yubo Peng1

  • 1The Center for Combinatorial Chemistry and Drug Discovery of Jilin University, The School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, P. R. China.

Organic Letters
|May 21, 2026
PubMed
Summary

A novel electroresponsive protecting group, 2-(2-pyridyl)ethyl (Pet), enables sustainable electrochemical deprotection. This method allows for mild cleavage of bonds, facilitating controlled release and scalable synthesis for research and therapeutics.

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