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Updated: May 22, 2026

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Published on: February 3, 2015
2-(2-Pyridyl)ethyl (Pet): An Electroresponsive Protecting Group for O/N Functionalities
Xin Wang1, Lianyou Zheng1, Yubo Peng1
1The Center for Combinatorial Chemistry and Drug Discovery of Jilin University, The School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, P. R. China.
Abstract:
Herein, we report the 2-(2-pyridyl)ethyl (Pet) moiety as a electroresponsive protecting group applicable to diverse O- and N-functionalities. A sustainable electrochemical deprotection strategy has been developed, enabling the selective cleavage of C-O and C-N bonds under mild conditions. This protocol facilitates scalable gram-scale synthesis and the controlled release of pharmaceuticals and natural products, offering a broadly applicable platform for biological research and therapeutic applications.
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