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Design of Antiacne Gel Containing Phloretin
Manu Sharma1, Vibha Kumari1, Meenakshi Bajpai1
1Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, 281406, India.
Summary
Phloretin, a natural compound, shows promise as an effective acne treatment. Its gel formulation demonstrated significant antibacterial activity and good drug release, offering a new option for managing acne vulgaris.
Area of Science:
- Dermatology and Pharmaceutical Sciences
- Natural Product Chemistry
Background:
- Acne vulgaris is a complex skin condition involving excess oil, blocked pores, and inflammation, with Staphylococcus aureus recognized as a contributing pathogen.
- Phloretin, a flavonoid from plants like apples, exhibits antioxidant, anti-inflammatory, and antibacterial properties relevant to acne treatment.
Purpose of the Study:
- To develop and evaluate a phloretin-based gel formulation for its potential as an effective anti-acne treatment.
- To assess the physicochemical properties, drug release, and antimicrobial efficacy of the developed gel.
Main Methods:
- Antiacne gels with varying Carbopol and phloretin concentrations were formulated.
- Evaluated parameters included physical appearance, viscosity, pH, drug content, in vitro drug release, and antimicrobial activity against Staphylococcus epidermidis.
Main Results:
- The optimized hydrogel (F4) showed a pH of 6.68, viscosity of 35.9 cP, and 80.9% drug content.
- In vitro studies achieved 75% drug release over 120 minutes, with significant antimicrobial activity (11 mm inhibition zone).
- The gel formulation was well-tolerated and showed no skin irritancy.
Conclusions:
- Phloretin-based gel is a promising anti-acne treatment with effective drug release and significant antibacterial activity against Staphylococcus epidermidis.
- The optimized formulation, containing phloretin, Carbopol, and other excipients, demonstrated superior antimicrobial results and acceptable dermatological properties.
