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Integrating Admission Hyperglycemia Into Multidisciplinary Risk Stratification for Sepsis in the ICU: A Retrospective
Natalia Tambunan1,2, Ayu Prawesti Priambodo3, Aan Nuraeni3
1Faculty of Nursing, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Journal of Multidisciplinary Healthcare
|May 21, 2026
Summary
Severe hyperglycemia on ICU admission significantly increases sepsis risk in critically ill patients. Early blood glucose screening and multidisciplinary management are vital for sepsis prevention and treatment.
Area of Science:
- Critical Care Medicine
- Metabolic Disorders
- Infectious Diseases
Background:
- Hyperglycemia is common in critically ill patients, linked to immune dysfunction and increased infection risk, including sepsis.
- Limited data exists on admission hyperglycemia as a sepsis predictor in developing nations like Indonesia.
- Managing hyperglycemia and sepsis requires a coordinated, multidisciplinary approach.
Purpose of the Study:
- To assess the independent association between admission hyperglycemia and sepsis incidence in intensive care unit (ICU) patients.
- To adjust for confounders like age, ICU stay duration, and comorbidities.
- To inform the development of collaborative clinical care pathways.
Main Methods:
- A retrospective cohort study of 290 adult ICU patients (January 2021-December 2025).
- Blood glucose levels categorized: euglycemia (71-140 mg/dL), mild hyperglycemia (141-200 mg/dL), severe hyperglycemia (>200 mg/dL).
- Sepsis diagnosed by attending physicians; data analyzed using multivariable logistic regression.
Main Results:
- Sepsis developed in 159 (54.8%) of patients.
- Severe admission hyperglycemia ( >200 mg/dL) was a significant predictor of sepsis (aOR=2.54, p=0.005).
- Advanced age (>65 years) and multiple comorbidities (≥2) were also independent predictors.
Conclusions:
- Severe admission hyperglycemia is a strong, independent predictor of sepsis in critically ill patients.
- Routine blood glucose screening upon ICU admission aids early risk stratification.
- A multidisciplinary protocol is essential for optimizing metabolic interventions and reducing sepsis burden.
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