Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Flail Chest-II01:26

Flail Chest-II

Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:
Flail Chest-I01:24

Flail Chest-I

Overview of Flail Chest
Flail chest is a severe and potentially life-threatening condition characterized by the fracture of three or more adjacent ribs in multiple places. It is most commonly caused by direct impacts and trauma, such as motor vehicle accidents or injuries from a steering wheel impact. It can also occur due to falls in elderly individuals with osteoporosis, or assaults involving sharp objects.
Pathophysiology
The pathophysiology of flail chest is complex, involving fractures of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transhumeral Amputation with Biceps Tenodesis Sling for Flail Shoulder After Irreversible Brachial Plexus Injury in the Setting of Bionic Reconstruction.

Journal of clinical medicine·2026
Same author

SMAS Plication Facelift and Platysmaplasty Under Tumescent Local Anesthesia: A 10-Year Retrospective Evaluation of Safety, Efficacy, and Patient Satisfaction in an Outpatient Setting.

Aesthetic plastic surgery·2026
Same author

Dupuytren's Disease of the Distal Interphalangeal Joint: A Systematic Review of Case Reports and Case Series.

Medicina (Kaunas, Lithuania)·2026
Same author

Dupuytren's Disease Extending into the Volar Pulp: A Case Report.

Reports (MDPI)·2026
Same author

Combined Abdominoplasty and Ventral Hernia Repair: A Systematic Review of Surgical and Patient-Centered Outcomes.

Aesthetic plastic surgery·2026
Same author

Double jersey finger: A systematic review and case series.

JPRAS open·2026

Related Experiment Video

Updated: May 22, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Timing of Flap Coverage in Open Fractures: A Systematic Review and Meta-Analysis.

Sina Dehnadi1, Rocio Pérez2, Ming Zien Yu3

  • 1Accident and Emergency, Royal Free Hospital NHS Foundation Trust, London, GBR.

Cureus
|May 21, 2026
PubMed
Summary

Early flap reconstruction for open tibial fractures within 72 hours significantly reduces complications like infection and osteomyelitis. Prioritizing timely orthoplastic care improves limb salvage and clinical outcomes for these severe injuries.

Keywords:
flap-based reconstructionlower limb traumaopen fracture woundsorthoplasticsystematic review and meta-analysistiming of the surgery

Related Experiment Videos

Last Updated: May 22, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Area of Science:

  • Orthoplastic Surgery
  • Trauma Management
  • Systematic Review and Meta-Analysis

Background:

  • Open tibial fractures are common and require orthoplastic management with flap reconstruction.
  • Early soft tissue coverage (within 72 hours) is crucial for reducing infection, promoting bone healing, and improving limb salvage.
  • Challenges in timely care delivery often lead to increased patient complications.

Purpose of the Study:

  • To systematically review and meta-analyze evidence comparing flap reconstruction within versus beyond 72 hours for open tibial fractures.
  • To assess the impact of timing on operative complications and clinical outcomes.
  • To evaluate the methodological quality of existing reviews and provide a high-confidence assessment.

Main Methods:

  • Systematic review and meta-analysis following PRISMA guidelines.
  • Searched six databases for comparative studies on flap reconstruction timing.
  • Assessed risk of bias using ROBINS-I and RoB2; evaluated evidence quality with GRADE and AMSTAR-2.

Main Results:

  • 14 articles comprising 2652 patients met inclusion criteria.
  • Early reconstruction (within 72 hours) was associated with fewer complications compared to delayed reconstruction.
  • Meta-analysis showed significantly lower risks of osteomyelitis (RR 0.28, CI 0.16-0.49) and trends towards reduced infection and amputation.

Conclusions:

  • Flap coverage within 72 hours is linked to improved clinical outcomes in open lower limb fractures.
  • Prioritization of early reconstruction is recommended when feasible.
  • Enhanced multidisciplinary coordination is needed to overcome delays and ensure timely specialist orthoplastic care.