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Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Related Experiment Video

Updated: May 22, 2026

Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence
09:11

Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence

Published on: January 27, 2023

Fusion Annotator: A Platform for Accelerating Consensus-Driven Ground Truth Generation with AI Assistance.

Suhas K C Kumar1, Fatemeh Afsari1, Nicholas Lucarelli1

  • 1Division of Nephrology, Hypertension, and Renal Transplantation-Quantitative Health Section, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL.

Proceedings of Spie--The International Society for Optical Engineering
|May 21, 2026
PubMed
Summary

Fusion Annotator accelerates AI development in renal pathology by enabling expert-driven, consensus-based digital annotation. This cloud-based platform standardizes dataset creation, overcoming limitations of traditional tools for computational pathology.

Keywords:
AI-assisted annotationCloud-based annotation platformDigital pathology annotationExpert consensus datasetsMachine learning for histopathologyRenal pathology

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Last Updated: May 22, 2026

Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence
09:11

Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence

Published on: January 27, 2023

Area of Science:

  • Computational pathology
  • Digital pathology
  • Artificial intelligence in medicine

Background:

  • AI advancements in pathology require high-quality annotated datasets for model development.
  • Renal pathology faces challenges in ground-truth generation due to complex workflows and variability.
  • Limited data accessibility and expertise hinder robust AI model creation in renal pathology.

Purpose of the Study:

  • To introduce Fusion Annotator, a novel cloud-first digital annotation platform.
  • To address the need for standardized, expert-driven dataset creation in renal pathology.
  • To accelerate the development of artificial intelligence models for computational renal pathology.

Main Methods:

  • Fusion Annotator is a web-based platform facilitating collaborative, consensus-oriented annotation.
  • It integrates with AI models to pre-identify regions of interest, reducing manual effort.
  • The platform supports customizable schemas, reference guidance, and multi-expert input for quality assurance.

Main Results:

  • Fusion Annotator enables secure, multi-institutional access and centralized data management.
  • It streamlines the creation of expert-annotated datasets for specific renal disease cohorts.
  • The platform facilitates consensus building and iterative refinement through pathologist feedback.

Conclusions:

  • Fusion Annotator overcomes limitations of traditional annotation tools for AI in renal pathology.
  • It provides a scalable solution for generating high-quality datasets essential for AI development.
  • The platform supports diverse renal pathology cohorts, advancing computational pathology research.