Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Modified-Release Drug Delivery Systems: Bioavailability01:30

Modified-Release Drug Delivery Systems: Bioavailability

Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrostatic regulation of solvation chemistry enables ampere-hour-scale high-energy lithium metal batteries.

Nature nanotechnology·2026
Same author

Cefdinir-Ornidazole for Bowel Preparation Before Colorectal Surgery: A Retrospective Cohort Study.

The Journal of surgical research·2026
Same author

Hydrophobic Microenvironment on Cu-Co Oxides for Dual Promotion of Mass Transfer and Electronic Regulation in Alkyl Aromatic Oxidation.

Inorganic chemistry·2026
Same author

Synergistic 3D Porous Architectures and Halogen Redox Chemistry for High-Energy and High-Power Microbatteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Nanoadjuvant-integrated organic biomaterials for immune engineering: Mechanisms, design strategies, and translational applications.

Materials today. Bio·2026
Same author

Clinical and genetic landscape of SCID in Yunnan, China: identification of two novel RAG2 variants.

Scientific reports·2026

Related Experiment Video

Updated: May 22, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Co-Encapsulation of Curcumin and Fucoxanthin With Multilayer Structural Nanoparticles: In Vitro Programmed Sequential

Luhui Wang1, Mingqing Wang1, Ling Lv2

  • 1Shandong Peanut Research Institute Qingdao China.

Food Science & Nutrition
|May 21, 2026
PubMed
Summary

This study developed multilayer structural nanoparticles (MSNPs) for sequential release of curcumin and fucoxanthin in the gastrointestinal tract (GIT). These food-grade nanoparticles enhance bioactive bioavailability by controlling release mechanisms across different GIT segments.

Keywords:
co‐delivery systemin vitro digestion modelmultilayer structural nanoparticlesprogrammed sequential releaserelease behavior

More Related Videos

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Related Experiment Videos

Last Updated: May 22, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Area of Science:

  • Food science and nanotechnology
  • Drug delivery systems
  • Nutraceutical formulation

Background:

  • Sequential release of multiple bioactives in the gastrointestinal tract (GIT) is crucial for enhancing bioavailability.
  • Current co-delivery systems often lack programmed release capabilities for targeted delivery.
  • Developing food-grade nanoparticles for controlled release of compounds like curcumin and fucoxanthin is an emerging research area.

Purpose of the Study:

  • To construct multilayer structural nanoparticles (MSNPs) for programmed sequential release of curcumin (Cur) and fucoxanthin (FUC).
  • To investigate the in vitro and in vivo release behavior of co-encapsulated bioactives within MSNPs.
  • To evaluate the impact of MSNPs on the bioavailability and biodistribution of Cur and FUC in vivo.

Main Methods:

  • Layer-by-layer self-assembly technique used to create MSNPs encapsulating gliadin, carboxymethyl konjac glucomannan, and chitosan hydrochloride.
  • In vitro digestion models simulating gastric, intestinal, and colonic environments to study release kinetics.
  • In vivo animal models employed to assess the bioavailability and biodistribution of encapsulated bioactives.

Main Results:

  • Curcumin release in simulated gastric fluid followed a diffusion and erosion mechanism.
  • Fucoxanthin release in simulated intestinal and colonic fluids was primarily governed by diffusion and erosion, respectively, influenced by β-mannanase.
  • MSNPs demonstrated a programmed switch from diffusion-controlled to erosion-controlled release across GIT segments.
  • In vivo studies confirmed enhanced bioavailability of outer-layer bioactives and reduced upper GIT biodistribution of inner-layer bioactives.

Conclusions:

  • MSNPs exhibit programmed sequential release behavior, transitioning release mechanisms along the GIT.
  • The developed food-grade MSNPs effectively enhance the bioavailability of co-delivered bioactives.
  • This research provides a foundation for advanced food-grade co-delivery systems with tailored release profiles.