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Identification of the Novel HLA-B*08:345Q Allele by Next-Generation Sequencing

Ruby J Siegel1, Katrin Hacke1, Catherine L Gebhart1

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, Arizona, USA.

HLA
|May 21, 2026
PubMed

Keywords:
HLA‐B*08:345Qnext generation sequencingnovel HLA allele

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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.