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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Updated: May 22, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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Published on: February 6, 2020

Bio-Based Covalent Adaptable Oligorotaxane Networks.

Wenbin Wang1,2, Ruixue Bai2,3, Wenzhe Gao2

  • 1Renji Branch of National Center For Translational Medicine, Shanghai Key Laboratory For Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.

Angewandte Chemie (International Ed. in English)
|May 21, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed sustainable, high-performance polymers using biomass and dynamic covalent chemistry. These novel bio-based covalent adaptable oligorotaxane networks offer robust mechanical properties and circular reprocessability.

Keywords:
bio‐based polymerscovalent adaptable networksintramolecular motionoligorotaxanesreprocessability

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Last Updated: May 22, 2026

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Nanosponge Tunability in Size and Crosslinking Density
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Published on: August 4, 2017

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Sustainable Materials

Background:

  • High-performance polymers from sustainable resources are crucial.
  • Dynamic covalent chemistry offers recyclability but faces mechanical trade-offs.
  • Mechanically interlocked architectures can enhance polymer properties.

Purpose of the Study:

  • To create bio-based polymers combining mechanical robustness, sustainability, and recyclability.
  • To integrate biomass feedstocks, dynamic covalent bonds, and mechanically interlocked architectures.
  • To develop a novel class of materials: bio-based covalent adaptable oligorotaxane networks (ORBCANs).

Main Methods:

  • Catalyst-free reactions between epoxidized soybean oil and topologically engineered polyrotaxanes.
  • Utilizing force-responsive behaviors inherent in polyrotaxanes.
  • Incorporating β-hydroxy ester linkages for dynamic transesterification.

Main Results:

  • ORBCANs exhibit significantly enhanced mechanical properties (Young's modulus, maximum stress, fracture strain, toughness) compared to controls.
  • The materials demonstrate efficient reprocessing at 110°C via dynamic transesterification.
  • Structural integrity and mechanical performance are retained after multiple reprocessing cycles.

Conclusions:

  • The synergistic integration of biomass, dynamic covalent bonds, and mechanically interlocked architectures yields high-performance, sustainable polymers.
  • ORBCANs offer a promising pathway to materials with robust mechanical properties, durability, and end-of-life recyclability.
  • This work bridges biomass-derived platforms and mechanically interlocked architectures for advanced polymer design.