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Updated: May 22, 2026

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Published on: October 13, 2016
Prefrontal and Occipital Network Excitability Differences in Dementia with Lewy Bodies and Alzheimer's Disease
Noa Bregman1,2,3, Noa Zifman4, Hilla Fogel4
1Cognitive Neurology Unit, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Abstract:
BackgroundThere is a great need in distinguishing Dementia with Lewy Body (DLB) from Alzheimer's disease (AD) and elucidating its pathophysiology. Transcranial magnetic stimulation (TMS) evoked potentials (TEPs) offer a non-invasive measure of neurophysiological alterations associated with underlying disease pathology.MethodsA total of 39 participants were included: 12 DLB, 10 AD, and 17 age-matched healthy controls (HC). TEPs were measured in the dorsolateral prefrontal cortex (DLPFC), primary motor cortex (M1), and primary visual cortex (V1).ResultsGlobal mean field potential (GMFP) TEP (130-250 ms) showed a significant interaction of group and stimulation site (p = .0101, ηp2 = 0.175) with a significant group effect (p = .0071, ηp2 = 0.234), attributed to higher GMFP in DLB compared to AD and HC in response to V1 stimulation (p = .001, p = .001, respectively). TEP amplitude corresponding to P60 displayed a significant group*stimulation site interaction (p = .0037, ηp2 = 0.202) arising from differences in DLPFC stimulation, between DLB compared to AD (p = .0013) and HC (p = .0032). DLPFC N45 presented a significant stimulation site effect not associated to a specific group in addition to DLPFC N45 amplitude being correlated to the UPDRS-III score (r = 0.9, p = .0002). A relative higher left over right DLPFC P30 amplitude was correlated with poorer MoCA scores in AD (r = -0.84, p = .002), as indicated by others before.ConclusionsDLPFC may be a target for both diagnosis and assessment of severity of motor symptoms in DLB and cognitive impairment in AD. These results propose a promising method to non-invasively distinguish DLB from AD and monitor disease, based on DLPFC and V1 network characteristics.
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