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Association Between Serum Atherogenic Index and Cardiovascular Disease in Early Adulthood: A Cohort Study

Mianwang He1, Nana Yin2, Chi Wang3

  • 1Department of Neurology, Chinese PLA General hospital, Chinese PLA Medical School, Beijing, China.

JACC. Asia
|May 21, 2026
PubMed

Insights

Higher atherogenic index of plasma (AIP) is linked to increased cardiovascular disease (CVD) and stroke risk in young adults. AIP can help identify individuals at higher risk for early cardiovascular events.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Biomarkers

Background:

  • The atherogenic index of plasma (AIP) is a novel marker for atherogenic risk.
  • Its association with cardiovascular disease (CVD) and mortality in young adults is not well-established.

Purpose of the Study:

  • To determine if AIP independently predicts CVD (including stroke) and all-cause mortality in young adults.
  • To assess AIP's utility in early cardiovascular risk stratification.

Main Methods:

  • Analysis of 64,416 participants aged 18-44 without prior CVD from the Kailuan Study (2006-2016).
  • AIP calculated at baseline, with participants stratified into quartiles.
  • Multivariable Cox models used to estimate hazard ratios (HRs) for CVD, stroke, and all-cause mortality, adjusted for multiple risk factors.

Main Results:

  • Over a mean follow-up of 14.65 years, higher AIP quartiles (Q2-Q4) were associated with increased risk of CVD and stroke compared to the lowest quartile (Q1).
  • HRs for CVD ranged from 1.16 to 1.36, and for stroke from 1.14 to 1.26.
  • No significant association was found between AIP and all-cause mortality after adjustment.

Conclusions:

  • Elevated AIP is an independent predictor of increased CVD and stroke risk in young adults.
  • AIP shows potential as a valuable biomarker for early cardiovascular risk assessment in this demographic.
Abstract

Keywords:
all-cause mortalityatherogenic index of plasmacardiovascular diseasesearly adulthoodstroke

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