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Rethinking the p-factor: A model of cumulative risk aggregation across development-Commentary on Caspi et al. (2026)
Andrea Raballo1, Michele Poletti2, Antonio Preti3
1University of Southern Switzerland, Faculty of Biomedical Sciences, REMEDI Lab Euler Institute.
Abstract:
Comments on the article by Caspi et al. (see record 2026-80066-001). The general psychopathology factor, or p-factor, has emerged as a latent structure capturing shared liability across mental disorders. However, it may reflect more than statistical covariance and instead index a developmental vulnerability architecture, an emergent feature shaped by genetic, social, and environmental interactions over time. Viewed in this way, the p-factor represents the trace of a deeper risk process unfolding across generations. This perspective supports integrative models of psychopathology and motivates transdiagnostic, network-based approaches to prediction and prevention. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
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