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Cedrela fissilis Vell. Inner Bark: LC-MS/MS-Based Chemical Profiling and Toxicological Effects
Thainá Pereira da Silva Cabral1, Emanuel Victor Dos Santos Nunes2, Viviani de Brito Massad Gomes da Silva1
1Institute of Chemistry, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil.
Chemistry & Biodiversity
|May 21, 2026
Summary
The hydroethanolic extract of Cedrela fissilis (HeECf) shows significant cytotoxic and genotoxic effects, impacting plant root growth and insect development. The ethyl acetate fraction (EA) exhibits lower toxicity, suggesting triterpenoids drive HeECf
Area of Science:
- Phytochemistry
- Toxicology
- Genetics
Background:
- Assessing plant extract toxicity is crucial for safety evaluations.
- Cedrela fissilis extracts require toxicological investigation for risk assessment.
Purpose of the Study:
- To evaluate the mechanistic toxicity of Cedrela fissilis hydroethanolic extract (HeECf) and its ethyl acetate (EA) fraction.
- To correlate chemical composition with observed toxicological effects.
Main Methods:
- Chemical profiling using LC-MS/MS.
- In vitro assays using Allium cepa and Chinese hamster ovary (CHO) cells.
- In vivo assays using Drosophila melanogaster.
Main Results:
- HeECf demonstrated significant cytotoxicity and genotoxicity in A. cepa and CHO cells, and inhibited D. melanogaster development.
- The EA fraction, enriched in flavonoids, showed markedly lower toxicity compared to HeECf.
- Pentacyclic triterpenoids in HeECf were identified as likely drivers of cytotoxic and genotoxic effects.
Conclusions:
- Cedrela fissilis HeECf possesses significant cytotoxic and genotoxic potential, mediated by triterpenoids.
- The EA fraction exhibits a safer toxicological profile.
- Triterpenoid-induced damage contributes to developmental disruption, highlighting the importance of chemical profiling in toxicity assessment.
