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Updated: May 23, 2026

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
Published on: March 10, 2023
Engineered enhancers: Using tumor switches for precision therapy
Weipeng Mo1, Wange Lu1, Nu Zhang2
1The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Abstract:
In a recent Nature article, Koeber et al. engineer synthetic super-enhancers from glioblastoma-specific regulatory circuitry to act as precise gene switches. Combined with viral delivery of cytotoxic and immune-stimulating payloads, this approach activates therapy selectively in tumor cells, enabling targeted tumor clearance and durable immune memory.
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