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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
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Published on: March 10, 2023

Engineered enhancers: Using tumor switches for precision therapy.

Weipeng Mo1, Wange Lu1, Nu Zhang2

  • 1The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.

Cancer Cell
|May 21, 2026
PubMed
Summary
This summary is machine-generated.

Researchers engineered synthetic super-enhancers to precisely control gene activity in glioblastoma. This targeted therapy approach clears tumors and establishes lasting immune memory.

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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunotherapy

Background:

  • Glioblastoma is an aggressive brain tumor with limited treatment options.
  • Targeted gene therapy requires precise control over therapeutic payload delivery.
  • Synthetic biology offers novel strategies for precise therapeutic control.

Purpose of the Study:

  • To engineer synthetic super-enhancers for precise gene regulation in glioblastoma.
  • To develop a targeted gene therapy approach for glioblastoma using synthetic super-enhancers.
  • To evaluate the efficacy of this approach in tumor clearance and immune memory induction.

Main Methods:

  • Engineering synthetic super-enhancers from glioblastoma-specific regulatory elements.
  • Utilizing viral vectors for payload delivery.
  • Incorporating cytotoxic and immune-stimulating payloads.

Main Results:

  • Synthetic super-enhancers demonstrated precise gene switching capabilities.
  • The approach enabled selective activation of therapy in tumor cells.
  • Effective targeted tumor clearance was achieved.
  • Durable immune memory was established.

Conclusions:

  • Synthetic super-enhancers offer a precise method for controlling gene therapy in glioblastoma.
  • This engineered gene-switching system holds promise for targeted cancer treatment.
  • The approach facilitates tumor eradication and long-term immune surveillance.