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HuR-HuB autoregulatory network governs inflammatory factors expression

Xingyue Fu1, Yuhan Lu1, Leying Kong1

  • 1Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun, Jilin, China.

The Journal of Biological Chemistry
|May 21, 2026
PubMed
Summary

Inflammation upregulates HuB protein, which binds HuR (human antigen R) to stabilize inflammatory factor mRNAs. This HuB-HuR interaction is crucial for regulating mRNA stability during inflammation.

Keywords:
HuBHuRinflammatory factorsmRNA stabilitypost-transcriptional regulation

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