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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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FDG PET for cardiac sarcoidosis: Protocol optimization, quantification, pitfalls, and multimodality imaging

Samuel B Wopperer1, Ellen Kronzer1, Joshua Ivare1

  • 1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Seminars in Nuclear Medicine
|May 21, 2026
PubMed
Summary

Cardiac sarcoidosis (CS) diagnosis is enhanced by multimodal imaging, particularly positron emission tomography (PET). Recent advancements in nuclear cardiology, including AI and new tracers, are improving CS patient management.

Keywords:
Cardiac sarcoidosisMultimodal imagingNuclear cardiologyPositron emission tomography

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Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging

Background:

  • Cardiac sarcoidosis (CS) presents heterogeneously, causing significant morbidity and mortality.
  • Common complications include heart failure, conduction abnormalities, arrhythmias, and sudden cardiac death.

Purpose of the Study:

  • To review the integration of multimodal imaging in diagnosing and managing CS.
  • To highlight advancements in positron emission tomography (PET) for CS diagnosis and management.

Main Methods:

  • Review of contemporary diagnostic strategies integrating echocardiography, cardiac magnetic resonance imaging, and PET.
  • Emphasis on recent nuclear cardiology advancements for CS.

Main Results:

  • Multimodal imaging, especially PET, is crucial for CS diagnosis.
  • Advancements include optimized PET protocols, quantitative analysis, serial imaging, AI applications, and novel PET tracers.

Conclusions:

  • PET imaging plays a pivotal role in the diagnosis and management of CS.
  • Emerging nuclear cardiology techniques are transforming clinical practice for CS patients.