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Related Experiment Video

Updated: May 23, 2026

Single-Molecule Measurement of Protein Interaction Dynamics Within Biomolecular Condensates
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Single-Molecule Measurement of Protein Interaction Dynamics Within Biomolecular Condensates

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Single-molecule electrical characterization of photoinduced aggregation evolution.

Rongqin Zhu1, Xiaoyan Xu2, Chenzi Li2

  • 1Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.

Nature Communications
|May 21, 2026
PubMed
Summary

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Researchers developed an electrical method to track molecular aggregation changes at the single-molecule level. This technique uses scanning tunneling microscopy to observe how molecules assemble and stabilize after light exposure, offering new insights into molecular dynamics.

Area of Science:

  • Molecular Science
  • Supramolecular Chemistry
  • Nanotechnology

Background:

  • Understanding molecular structural evolution during photoinduced aggregation in solution is a significant challenge.
  • Dynamic aggregation processes in solution require advanced characterization techniques.
  • Current methods often lack the resolution to track real-time structural changes at the single-molecule level.

Purpose of the Study:

  • To develop an electrical strategy for characterizing photoinduced aggregation at the single-molecule level.
  • To monitor the dynamic structural evolution of molecules during light-driven assembly.
  • To correlate molecular geometry changes with electrical conductance signatures.

Main Methods:

  • Utilized persulfurated arenes as a model system for photoinduced aggregation studies.

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Last Updated: May 23, 2026

Single-Molecule Measurement of Protein Interaction Dynamics Within Biomolecular Condensates
06:48

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Published on: January 5, 2024

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  • Employed scanning tunneling microscope-break junction (STM-BJ) measurements to detect single-molecule conductance.
  • Conducted time-dependent irradiation experiments to observe aggregation progression.
  • Performed complementary theoretical analyses to correlate molecular geometry with conductance.

    • Main Results:

    • Photoexcitation was shown to enhance intermolecular interactions, driving molecular assembly and conformational stabilization.
    • Stabilized aggregated species exhibited distinct ratiometric conductance signatures detectable by STM-BJ.
    • Time-resolved experiments successfully monitored the progressive evolution of aggregation and structural changes.
    • Theoretical calculations confirmed the relationship between molecular geometry and measured conductance.

    Conclusions:

    • Established a direct link between the evolution of photoinduced aggregation and single-molecule conductance.
    • Demonstrated an electrical approach for investigating structural dynamics in photoresponsive molecular assemblies.
    • Provided a novel electrical perspective for understanding dynamic processes in molecular science.