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Published on: November 9, 2019
Total syntheses of (+)-dalesconols A and B enabled by triple-relayed remote chirality transfer
Yun Guo1, Jingjing Liu1, Wen Gao1
1Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, China.
Abstract:
Dalesconols A and B, featuring unique and highly congested polycyclic carbon frameworks and notable biological activities, have attracted sustained attention. However, their structural complexity constitutes a significant challenge for total synthesis. Herein, we present the asymmetric total syntheses of (+)-dalesconols A and B via a remote chirality transfer strategy. Central to this approach is the implementation of our palladium/norbornene-catalyzed trifunctionalization method, which enables one-step construction of the chiral polycyclic core skeleton via a triple relay of point-to-axial, axial-to-axial, and axial-to-point chirality transfer. Combined with intramolecular Michael addition, C-H oxidation/retro-Michael elimination, and global demethylation, this triple-relayed remote chirality transfer strategy allows concise and modular access to (+)-dalesconols A and B.
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