Related Experiment Video
Updated: May 23, 2026
08:33
A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
Published on: January 5, 2024
Cipepofol for adjunctive sedation during neuraxial anesthesia: a study protocol for a randomized controlled trial
Mi Chen1, Lirong Chen2, Yang Yang1
1Department of Anesthesiology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550004, China.
Trials
|May 22, 2026
Summary
Cipepofol shows comparable efficacy and safety to propofol for sedation during neuraxial anesthesia. This novel phenol derivative offers a potential alternative for clinical sedation practices.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Cipepofol is a novel 2,6-disubstituted phenol derivative.
- It is increasingly used for anesthesia and sedation during gastrointestinal endoscopy and fiberoptic bronchoscopy.
Purpose of the Study:
- To evaluate the efficacy and safety of cipepofol as an adjunctive sedative during neuraxial anesthesia.
- To provide evidence for the clinical application of cipepofol in this setting.
Main Methods:
- A randomized, double-blind, non-inferiority trial comparing cipepofol and propofol.
- Target sedation level defined by Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score of 3-4.
- Primary outcome was sedation success rate; secondary outcomes included time to sedation, recovery, and patient/clinician satisfaction.
Main Results:
- Sedation success rates were comparable between cipepofol and propofol groups.
- Time to recovery and patient satisfaction were similar between the two groups.
- Cipepofol demonstrated a favorable safety profile with no significant differences in adverse events.
Conclusions:
- Cipepofol is an effective and safe alternative to propofol for adjunctive sedation during neuraxial anesthesia.
- Its comparable efficacy and safety profile support its clinical use.
- Further research may explore its utility in diverse patient populations and procedural settings.
Related Concept Videos
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
01:29Local Anesthetics: Clinical Application as Epidural Anesthesia
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
01:09Peripherally and Centrally Acting Muscle Relaxants: A Comparison
Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic drugs,...
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic drugs,...
01:24Parenteral Anesthetics: Overview
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.