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Updated: May 23, 2026
09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
Liver-nervous system axis: pathways, dysregulation, and translational perspectives
Donglin Hao1,2, Yuebo Hu3, Wei Luo1
1Department of Laboratory Medicine, Wujin Hospital Affiliated With Jiangsu University, Jiangsu University, Changzhou, 213017, China.
Journal of Neuroinflammation
|May 22, 2026
Summary
The liver-nervous system axis regulates body homeostasis, but its disease mechanisms are unclear. This study clarifies liver-brain interactions to identify new therapeutic targets.
Area of Science:
- Neuroscience
- Hepatology
- Physiology
Background:
- The liver and nervous system interact via a bidirectional regulatory network, essential for homeostasis.
- Mechanisms underlying liver-nervous system communication in disease are not fully understood.
- Blood-brain barrier transport of liver metabolites requires further elucidation.
Purpose of the Study:
- To systematically review recent advances in liver-brain axis research.
- To elucidate coordinated regulatory patterns under physiological and pathological conditions.
- To identify potential therapeutic targets for liver and nervous system disorders.
Main Methods:
- Integration of research on liver innervation and neuroregulatory effects of liver substances.
- Analysis of trans-organ inflammatory mediator conduction.
- Inclusion of clinical evidence from interventions like beta-blockers and vagus nerve stimulation.
Main Results:
- The study provides a comprehensive overview of the liver-brain axis.
- It details physiological regulatory patterns and pathological interaction mechanisms.
- It highlights the role of liver metabolites and inflammatory mediators in inter-organ communication.
Conclusions:
- Understanding the liver-brain axis is crucial for metabolic and immune homeostasis.
- Disruptions in this axis contribute to disease pathogenesis.
- This review offers a theoretical basis and potential therapeutic strategies for related diseases.
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