Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 23, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Time to Treatment Initiation Analysis in Patients with Localized Extremity Non-Small Round Cell Sarcoma.

Sakurako Takahashi1, Masatake Matsuoka1, Tomohiro Onodera1

  • 1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, Japan.

Asian Pacific Journal of Cancer Prevention : APJCP
|May 22, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Femur-referenced 3D-CT detects patellar height decrease and its correlation with correction magnitude after opening-wedge high tibial osteotomy: Comparison with conventional radiographic indices.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association·2026
Same author

Oral contraceptive-associated hypertension as an under-recognized contributor to secondary and apparent resistant hypertension: agent-specific blood pressure liability, RAAS testing pitfalls, and practical assessment.

Hypertension research : official journal of the Japanese Society of Hypertension·2026
Same author

Effects of Medial Opening-Wedge High Tibial Osteotomy on 3-Dimensional Knee Joint Biomechanics and Trunk Posture.

Orthopaedic journal of sports medicine·2026
Same author

Maternal Complications and Facility-Level Differences in the Management of Placental Abruption in Japan: A Retrospective Analysis Using a Multicenter DPC Database.

The journal of obstetrics and gynaecology research·2026
Same author

Four-dimensional computed tomography can visualise the in vivo glenoid track and quantify dynamic glenohumeral contact mechanics during active motion in subjects with shoulder instability: A preliminary study.

Journal of experimental orthopaedics·2026
Same author

Tenapanor-Associated Bowel Effects in Hemodialysis: Persistence Barriers and Practical Continuation Strategies.

Hemodialysis international. International Symposium on Home Hemodialysis·2026

Delayed time-to-treatment initiation (TTI) negatively impacts survival for localized extremity non-small-round-cell sarcoma (NSRCS) patients. Adjuvant therapies may help reduce survival risks associated with delayed TTI.

Area of Science:

  • Oncology
  • Cancer Research
  • Sarcoma Treatment

Background:

  • Time-to-treatment initiation (TTI) is a critical factor in cancer survival.
  • The impact of prolonged TTI on localized extremity non-small-round-cell sarcoma (NSRCS) survival is not well-established.

Purpose of the Study:

  • To investigate the association between TTI and overall survival (OS) in patients with localized extremity NSRCS.
  • To explore the potential role of adjuvant therapies in mitigating survival disparities related to TTI.

Main Methods:

  • Utilized SEER database data from 11,380 localized extremity NSRCS patients (2000-2019).
  • Employed Kaplan-Meier analysis and Cox proportional hazards models to assess TTI and OS.
  • Categorized patients into TTI cohorts: <1 month, <2 months, and <4 months.
Keywords:
SEER programSoft tissue sarcomaTreatment outcomeneoplasm gradingretrospective study

Related Experiment Videos

Last Updated: May 23, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Main Results:

  • Delayed TTI showed minimal impact on OS compared to <1 month TTI (HR=1.01).
  • Significant worse OS was observed for delayed TTI in the <2 months (HR=1.10) and <4 months (HR=1.30) cohorts.
  • Adjuvant therapies (chemotherapy, radiation) may offset decreased survival from TTI delay.

Conclusions:

  • Delayed TTI adversely affects survival in localized extremity NSRCS patients.
  • Adjuvant therapy presents a potential strategy to mitigate negative survival outcomes associated with TTI delay.