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Related Experiment Video

Updated: May 23, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
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ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

Second-look endoscopy does not reduce delayed bleeding after endoscopic papillectomy: a multicenter propensity

Yuki Fujii1, Kazuyuki Matsumoto2, Toru Ueki3

  • 1Department of Endoscopy, Okayama University Hospital, Okayama, Japan.

Therapeutic Advances in Gastroenterology
|May 22, 2026
PubMed

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Summary

Routine second-look endoscopy (SLE) after endoscopic papillectomy (EP) does not prevent delayed bleeding. Prophylactic hemostasis during SLE is not recommended for asymptomatic patients, as it may prolong hospital stays without benefit.

Area of Science:

  • Gastroenterology
  • Endoscopic Procedures
  • Surgical Complications

Background:

  • Delayed bleeding is a significant complication following endoscopic papillectomy (EP).
  • Second-look endoscopy (SLE) is commonly used for post-EP assessment, but its efficacy in preventing bleeding is uncertain.

Purpose of the Study:

  • To evaluate the effectiveness of routine second-look endoscopy (SLE) in preventing delayed bleeding after endoscopic papillectomy (EP).
  • To identify risk factors for delayed bleeding and assess the impact of prophylactic hemostasis during SLE.

Main Methods:

  • A multicenter, retrospective cohort study involving 132 patients who underwent EP.
  • Propensity score matching was used to compare outcomes between patients who had SLE (n=73) and those who did not (n=59).
Keywords:
delayed bleedingendoscopic papillectomypost-resection siteprophylactic hemostasissecond-look endoscopy

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Last Updated: May 23, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

  • Primary outcome was delayed bleeding; secondary outcomes included risk factors and hospitalization duration.

    • Main Results:

    • After matching, no significant difference in delayed bleeding rates was observed between the SLE and non-SLE groups (14% vs. 9%, p=0.50).
    • Lack of preventive clipping closure was identified as the sole independent risk factor for delayed bleeding (OR 15, p=0.030).
    • Prophylactic hemostasis during SLE did not reduce bleeding but was associated with longer hospital stays (13 vs. 9 days, p=0.012).

    Conclusions:

    • Routine second-look endoscopy (SLE) does not appear to reduce the incidence of delayed bleeding after endoscopic papillectomy (EP).
    • Prophylactic hemostasis in asymptomatic patients undergoing SLE may lead to unnecessarily prolonged hospitalization.
    • Hemostatic interventions should be reserved for patients exhibiting clinical signs of bleeding.