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Published on: June 4, 2017

Severity-Dependent Association Between Allergic Rhinitis and Adenoid Hypertrophy in Dust Mite-Sensitized Children

Bo Zhao1, Yang Wang2, Hongyang Zhang2

  • 1Center of Stomatology, The Second Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.

Journal of Asthma and Allergy
|May 22, 2026
PubMed

Insights

Allergic rhinitis severity is linked to more severe adenoid hypertrophy in children sensitized to dust mites. Controlling allergic rhinitis early is crucial to prevent worsening adenoid enlargement.

Area of Science:

  • Pediatric Allergy and Immunology
  • Otolaryngology
  • Respiratory Medicine

Background:

  • Allergic rhinitis (AR) and adenoid hypertrophy (AH) frequently co-occur in children.
  • The precise relationship between AR severity and the degree of adenoid enlargement needs further clarification.

Purpose of the Study:

  • To investigate the association between allergic rhinitis severity, allergic inflammatory burden, and the extent of adenoid hypertrophy in children sensitized to dust mites.

Main Methods:

  • Cross-sectional study of 170 dust mite-sensitized children with AR.
  • Adenoid hypertrophy assessed via nasal endoscopy (Grade III vs. IV).
  • AR severity evaluated using TNSS, VAS, PRQLQ-S; inflammatory markers included peripheral eosinophils, total IgE, and specific IgE to Dermatophagoides species.

Main Results:

  • Grade IV AH correlated with significantly higher TNSS, VAS scores, and nasal symptom burden (P < 0.001).
  • TNSS, VAS, and PRQLQ-S showed moderate positive correlations with choanal obstruction percentage (P < 0.001).
  • Eosinophil counts, total IgE, and dust mite-specific IgE levels weakly but significantly correlated with adenoid obstruction.

Conclusions:

  • AR severity demonstrates a positive, dose-dependent association with AH in dust mite-sensitized children.
  • Adenoid enlargement is linked to clinical and immunological markers of allergic inflammation.
  • Early and effective allergic rhinitis control is important for preventing progressive adenoid hypertrophy.
Abstract

Keywords:
AHallergenallergic rhinitisallergydust mite-sensitized

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