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Published on: September 27, 2024

Colorectal Cancer Treatment During Pregnancy.

Kathryn L Green1, Rachel Hatch1

  • 1From Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.

Journal of the Advanced Practitioner in Oncology
|May 22, 2026
PubMed
Summary
This summary is machine-generated.

This case study explores treating colorectal cancer (CRC) during pregnancy. Chemotherapy was safely administered in the second and third trimesters, resulting in a healthy infant delivery.

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Area of Science:

  • Oncology
  • Maternal-Fetal Medicine
  • Reproductive Health

Background:

  • Colorectal cancer (CRC) is rare in pregnancy, affecting approximately 1 in 13,000 pregnancies in the US.
  • Chemotherapy during pregnancy poses risks to the fetus, often leading to treatment delays.
  • Managing cancer during gestation requires careful risk-benefit assessment for both mother and child.

Purpose of the Study:

  • To present a unique case of successful colorectal cancer treatment during pregnancy.
  • To discuss oncologic therapies applicable to pregnant patients with CRC.
  • To highlight key considerations for CRC diagnosis and management in pregnant individuals.

Main Methods:

  • Case report of a 36-year-old pregnant patient diagnosed with colorectal cancer.
  • Review of chemotherapy administration during the second and third trimesters.
  • Discussion of maternal and fetal outcomes.

Main Results:

  • The patient received chemotherapy during pregnancy and delivered a healthy baby at 34 weeks gestation.
  • The case demonstrates the feasibility of managing CRC during pregnancy.
  • Specific oncologic therapies for pregnant patients were reviewed.

Conclusions:

  • Colorectal cancer can be managed during pregnancy with careful consideration of treatment timing and modality.
  • Chemotherapy can be a viable option in select pregnant patients with CRC, balancing maternal health and fetal well-being.
  • This case underscores the importance of multidisciplinary care for pregnant patients with cancer.