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Related Concept Videos

Stages of Infection01:26

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
Classification of Illness01:17

Classification of Illness

The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
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Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
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Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
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Related Experiment Video

Updated: May 23, 2026

COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah
04:43

COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah

Published on: June 24, 2025

Good? A very long COVID-19.

Quentin Philippot1,2, Marie-Pierre Debray2,3, Alice Guyard2,4

  • 1Service de Pneumologie, Allergologie et Transplantation, Hôpital Bichat Claude Bernard, AP-HP, Paris, France.

Journal of Human Immunity
|May 22, 2026
PubMed
Summary
This summary is machine-generated.

A patient with Good syndrome experienced chronic SARS-CoV-2 infection due to poor B cell immunity. Immunoglobulin replacement therapy effectively resolved symptoms and radiological findings.

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Last Updated: May 23, 2026

COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah
04:43

COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah

Published on: June 24, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

Area of Science:

  • Immunology
  • Infectious Diseases
  • Genetics

Background:

  • Good syndrome is a rare primary immunodeficiency characterized by thymoma and various immune defects.
  • Impaired B cell function can lead to susceptibility to opportunistic infections and poor response to viral pathogens.

Purpose of the Study:

  • To describe a case of chronic SARS-CoV-2 infection in a patient with Good syndrome.
  • To investigate the role of B cell immunity in persistent SARS-CoV-2 infection.
  • To evaluate the efficacy of immunoglobulin replacement therapy.

Main Methods:

  • Case report detailing clinical presentation, immunological workup, and treatment of a patient with Good syndrome and chronic SARS-CoV-2.
  • Assessment of B cell function and SARS-CoV-2 specific antibody levels.
  • Monitoring of clinical and radiological parameters before and after treatment.

Main Results:

  • The patient presented with persistent SARS-CoV-2 infection attributed to impaired B cell-mediated immunity.
  • Immunoglobulin replacement therapy led to significant clinical improvement and radiological resolution of infection.
  • Restoration of humoral immunity markers was observed post-therapy.

Conclusions:

  • B cell dysfunction in Good syndrome can predispose individuals to chronic viral infections like SARS-CoV-2.
  • Immunoglobulin replacement therapy is a viable treatment option for chronic SARS-CoV-2 in immunocompromised patients.
  • This case highlights the importance of addressing humoral immunodeficiency in managing persistent viral infections.