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Bibliometric analysis and data visualization on drug delivery systems for infectious keratitis
Sha Ouyang1, Guoping Yang2,3, Yang Yang4
1Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Summary
Research on drug delivery systems (DDS) for infectious keratitis shows increasing global interest, with a shift towards advanced nanocarrier strategies. China leads publications, while the USA shows high academic influence.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Biomedical Engineering
Background:
- Infectious keratitis poses a significant threat to vision.
- Effective drug delivery systems (DDS) are crucial for treating infectious keratitis.
- Advancements in DDS aim to improve therapeutic efficacy and patient outcomes.
Purpose of the Study:
- To conduct a bibliometric analysis of research on DDS for infectious keratitis from 2006 to 2025.
- To identify research trends, key hotspots, and collaboration patterns in this field.
- To visualize the evolution and landscape of DDS research for infectious keratitis.
Main Methods:
- Systematic literature search in the Web of Science Core Collection (2006-2025).
- Data extraction and analysis using bibliometric tools: GraphPad Prism, CiteSpace, and VOSviewer.
- Visualization of publication trends, country/institution contributions, keyword co-occurrence, and citation networks.
Main Results:
- Publication output and citations have steadily increased over two decades.
- China leads in publications (137 papers), while the USA demonstrates high academic influence (betweenness centrality).
- Key research themes include drug delivery, nanoparticles, fungal keratitis, sustained release, hydrogels, liposomes, and 3D printing.
Conclusions:
- The field of DDS for infectious keratitis is rapidly evolving, with a growing global research focus.
- Research is shifting from traditional formulations to innovative nanocarrier strategies.
- Interdisciplinary collaboration is essential for addressing safety, scalability, and clinical translation challenges.
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