Related Experiment Video
Updated: May 24, 2026

Localization and Relative Quantification of Carbon Nanotubes in Cells with Multispectral Imaging Flow Cytometry
Published on: December 12, 2013
Cross-scale attention network for automated carbon nanomaterial recognition in TEM images
Wenbo Liu1, Yanyan Cui2, Minghui He3
1South China University of Technology, School of Light Industry Technology and Engineering, Guangzhou, Guangdong 510640, China; Guangzhou new chemical material technology LTD, Guangzhou, Guangdong 510640, China.
Abstract:
Automated interpretation of transmission electron microscopy (TEM) images for nanomaterial classification remains challenging due to complex multi-scale structural patterns, heterogeneous imaging conditions, and limited annotated data. Conventional convolutional neural networks (CNNs) typically operate on single-resolution inputs and single-stream architectures, which restrict their ability to simultaneously capture global morphology and fine structural details essential for distinguishing similar nanomaterial classes. To address these limitations, we propose a multi-resolution, multi-depth CNN architecture with cross-resolution fusion and an auxiliary supervised attention module (ASAM). The framework processes images through parallel resolution-specific branches and integrates features bidirectionally across scales and depths using max-pooling and transposed convolution operations. Auxiliary supervision is introduced at intermediate depths to guide discriminative feature learning and enhance convergence stability. The proposed method was evaluated on a dataset of 5,323 TEM images comprising five categories of carbon-based nanostructures using five-fold cross-validation. Experimental results show that the proposed model achieves an overall accuracy of 94.8%, precision of 94.1%, recall of 94.5%, and F1-score of 94.3%, outperforming baseline models including VGG-16 (84.3% accuracy), ResNet-50 (88.5%), U-Net (90.2%), and EfficientNet (90.3%). Ablation analysis further demonstrates that the auxiliary supervised attention module improves accuracy from 92.5% to 94.8%. These results indicate that the proposed framework provides a robust and scalable expert system for high-throughput TEM-based nanomaterial classification.
