Advances and Challenges in Sepsis Care in Low-Resource Settings

Sepsis is a leading cause of death worldwide, disproportionately affecting low-resource settings. Limited diagnostics, antimicrobial resistance, and scarce critical care capacity compound the burden. Areas for improved care include physiology-based triage, point-of-care lactate testing, and simplified severity scores for early recognition. Context-specific strategies favor cautious fluid resuscitation, safe peripheral vasopressor use, improved oxygen systems, and portable ultrasound for monitoring and source control. Expanding access to microbiology and tailored antimicrobial stewardship remain critical. Sustainable progress depends on workforce training, system strengthening, and context-appropriate guidelines. Locally driven research and global investment are essential to achieve equity in sepsis care delivery.