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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
A Hybrid Pipeline for Mapping French UCD Drug Codes to RxNorm with Dosage Preservation
Boris Delange1, Mathilde Bories1, Sylvain Robert1
1CHU Rennes, INSERM, LTSI-UMR 1099, Univ Rennes, 35000 Rennes, France.
Abstract:
The Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) requires drug data to be encoded in RxNorm for interoperable and dose-aware analyses. In France, medications are identified using UCD and CIP codes, but no direct mapping exists between UCD and RxNorm. We developed an automated three-stage pipeline to map French UCD codes to RxNorm Clinical Drugs while preserving dosage information. The process combined reference-based mapping using the French Drug Nomenclature (RUIM) and OHDSI Standardized Vocabularies, rule-based similarity matching, and agentic AI reasoning, with expert validation at each stage. Applied to the 38,345 UCD codes from the French national nomenclature, the pipeline achieved a 97.4% mapping rate with 86.0% precision when evaluated on the 500 most frequently used codes. This approach provides a reproducible and scalable framework for drug terminology harmonization in OMOP ETL processes.
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